Sickle Cell Simulation

Explore the connection between DNA, protein structure, and disease with the Sickle Cell Simulation from PEEBEDU. This interactive biology simulation lets you select genotypes for two copies of the HBB gene on chromosome 11 ; choosing between the normal HbA allele and the sickle HbS allele. Instantly see how a single nucleotide substitution changes the mRNA codon and alters red blood cell shape. Watch an animated blood vessel respond in real time as normal round cells flow freely and sickled cells clump and block circulation. Toggle malaria exposure to discover why heterozygous carriers (HbA/HbS) have a survival advantage in malaria-endemic regions, illustrating the concept of heterozygote advantage.