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Enzyme Chaser

Enzymes are often taught as separate rules about inhibitors, temperature and pH. This game turns them into one idea: an enzyme works only when a substrate fits its active site. You play an enzyme that is never used up, and each of the six levels adds one condition. Inside a membrane, the reaction slows as substrate runs out and products crowd in. Competitive inhibitors block the active site; noncompetitive inhibitors bind elsewhere and bend it out of shape. Warm water speeds up every molecule, so enzyme and substrate meet more often, until extreme heat unfolds the enzyme for the rest of the level. Acidic or basic water changes its shape and charge, but in this game it recovers soon after swimming out. A classmate's replication shows why repeatable results are trusted. Then you design your own experiment, changing one variable at a time.

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AP / College Student HandoutDownload PDF

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