PEEBEDU

Alcohol Metabolism Explorer

ADH1B

Alcohol Dehydrogenase 1B

Chromosome 4

Karyotype

Allele 1

DNA: TGCAAG

RNA: ACGUUC

Amino Acids:

Thr Arg

Allele 2

DNA: TGCAAG

RNA: ACGUUC

Amino Acids:

Thr Arg

Protein Structure

Phenotype

Acetaldehyde Production Rate

Typical Metabolism

Case Study:

ALDH2

Aldehyde Dehydrogenase 2

Chromosome 12

Karyotype

Allele 1

DNA: ACCGAA

RNA: UGGCUU

Amino Acids:

Trp Glu

Allele 2

DNA: ACCGAA

RNA: UGGCUU

Amino Acids:

Trp Glu

Protein Structure

Phenotype

🙂

No Flush

Case Study:

Test Your Knowledge

Question 1 of 10

How Your Body Processes Alcohol

ADH1B enzyme ALDH2 enzyme Ethanol → Acetaldehyde → Acetate

Special proteins called enzymes break down alcohol. This app explores the two key enzymes in this pathway. Acetaldehyde is a toxic compound that can make you feel unwell.

Your DNA Makes the Difference

🧬 → 🧩 → 😊/😳

DNA Protein Trait

Your genotype (your specific DNA sequence) provides the instructions to build these enzymes. A tiny change in the DNA, called a mutation, can change the enzyme's shape and how well it works. This results in a different phenotype—an observable trait like facial flushing.

You're in Control

In each panel, you have two copies of each gene—one from each parent. Use the dropdowns to select different alleles (versions of a gene) and see how they combine to affect the trait. Or, select a case study to see a real-world example.

Click 'Begin' to start!