Master the cellular protein processing pathway through interactive learning
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Welcome!
Discover how proteins travel through cellular organelles, undergo modifications,
and reach their final destinations in this interactive journey.
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Step 1: ER Synthesis
Proteins are created by ribosomes attached to the Endoplasmic Reticulum (ER)
The ER is like a protein factory where ribosomes act as assembly machines,
reading genetic instructions to build proteins one amino acid at a time.
This is where your protein's journey begins!
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Step 2: Create Vesicle
Drag the protein from the ER to package it into a transport vesicle
Think of vesicles as cellular delivery trucks. When you drag a protein away from the ER,
it gets wrapped in membrane and becomes ready for transport to its next destination.
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Step 3: Golgi Transport
Move the vesicle to the Golgi apparatus for processing
The Golgi apparatus is like a post office sorting center. Proteins arrive here to be
modified, packaged, and labeled with their final destination addresses.
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Step 4: Protein Modifications
Apply modifications in the Golgi to prepare proteins for their roles
Glycosylation
Add sugar chains for cell recognition
P
Phosphorylation
Add phosphate groups for regulation
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Cleavage
Cut proteins to activate them
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Step 5: Final Delivery
Package and deliver proteins to their final destinations
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Cell Membrane
Proteins become part of the cell surface or are secreted outside
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Lysosome
Proteins help digest materials and recycle cellular components
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Your Learning Objectives
Complete these tasks to master protein processing:
Apply glycosylation to a protein
Apply phosphorylation to a protein
Cleave a protein
Deliver protein to cell membrane
Deliver protein to lysosome
Complete all objectives to master protein processing!
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🧠 Test Your Knowledge
Challenge yourself with questions about protein processing!
Protein Modification and Shipping Visualizer
Cytosol
ER (Synthesis)
Endoplasmic Reticulum: Where proteins are synthesized by ribosomes and begin their folding process
Golgi Apparatus
Cis Face
Medial
Trans Face
Processing & packaging center: Modifies proteins with sugars and phosphates, then sorts them for delivery
Lysosome
Cellular recycling center: Contains digestive enzymes to break down waste. Phosphorylated proteins often come here
Cell Membrane
Cell boundary: Proteins can be embedded here as receptors/channels or secreted outside. Glycosylated proteins often end up here
(Secretion / Embedding)
Extracellular Solution
Objectives
Apply glycosylation to a protein
Apply phosphorylation to a protein
Cleave a protein
Deliver protein to cell membrane
Deliver protein to lysosome
Welcome!
Drag the protein from the ER to begin its journey.